Brand name: allopurinol
Generic name: Zyloprim, Zyloric, Progout, Allohexal, Puricos, Allosig

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Allopurinol is in the following drug classes: antigout agents, antihyperuricemic agents. It is not known whether this potentiation of ampicillin rashes is due to allopurinol or the hyperuricemia present in these patients. HypersensitivityA case study suggests cell-mediated immunity to allopurinol and oxypurinol is involved in allopurinol-induced hypersensitivity reactions. Allopurinol is used to treat the following conditions: Calcium Oxalate Calculi with Hyperuricosuria, Cardiothoracic Surgery, Gout, Heart Failure, High Risk Percutaneous Transluminal Angioplasty, Hyperuricemia Secondary to Chemotherapy, Leishmaniasis, Mania, Reactive Perforating Collangenosis, Urinary Tract Stones. At least 3 cases of allopurinol hypersensitivity syndrome have also been reported. There is a case report of a patient with no history of psychiatric disease whose allopurinol-associated catatonia, rash, and fever responded to steroids. Past experience suggested that the most frequent event following the initiation of allopurinol treatment was an increase in acute attacks of gout (average 6% in early studies). A 43-year-old female with chronic kidney disease developed fever, generalized morbilliform rash, leukocytosis with marked eosinophilia, and hepatic dysfunction 3 weeks after starting allopurinol therapy (300 mg/day for 3 days followed by 200 mg/day) for hyperuricemia and arthritis. The addition of allopurinol may help to protect the renal tubules from long-term damage due to uric acid crystallization. Biopsies in cases of suspected allopurinol-associated acute renal failure have revealed vasculitis, interstitial nephritis, and rare cases of granulomatous nephritis. Careful dosage instructions should be given to the patient, especially when azathioprine is being administered in the presence of impaired renal function or concomitantly with allopurinol (see DOSAGE AND ADMINISTRATION and Drug Interactions under PRECAUTIONS). Eleven days later (approximately 7 weeks after allopurinol was discontinued), both the hemoglobin level and reticulocyte count began to rise.

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